The melatonin, a hormone that regulates sleep, could be indicated for prevent damage caused by coronavirus to the central nervous system, according to a study recently published by Argentine researchers in the scientific magazine Melatonin Research.
“Although in patients infected with COVID-19 clinical findings indicate that excessive inflammation and a depressed immune system contribute substantially to lung disease, Other evidence suggests that the infectious picture may have a neurological origin.“he told the Tlam news agency Daniel Cardinali, researcher at the Faculty of Medical Sciences of the Argentine Catholic University (UCA).
Author of the recent publication “High doses of melatonin as a potential therapeutic tool for the neurological sequelae of Covid-19 infection,” Cardinali noted that this hormone is known for its sleep regulating effect it has powerful effects like “antioxidant, anti-inflammatory and immunostimulantAlso, he noted, melatonin “fulfills a protective action of the renin-angiotensin system that regulates an enzyme (ECA2) that is key in the entry of the SARS-Cov-2 to the cells. “
The specialist described that “uncontrolled infection with COVID-19 is accompanied by a generalized inflammatory picture and immunosuppression” and, in this context, “the administration of melatonin dosage in the order of the 100 milligrams daily could block the inflammatory picture and reverse immunosuppression, as revealed by the first series of patients examined in the international literature. “
In the article, Cardinali describes from the animal studies the potentially adequate dose in humans for prevent the impact on the central nervous system of coronavirus infection. Currently, there are at least three clinical studies in Spain who use melatonin, targeting prevention in health personnel and treatment of seriously ill patients in Intensive Care Units (ICU), the researcher explained.
Recent work on a population of 11,672 cases verified that In patients receiving this hormone, the incidence of infection was significantly lower.Cardinali described. He concluded that, in addition, “melatonin has a high security profile, is low cost and can be self-administered so it becomes an attractive preventive treatment. “